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Personalyzed One Carbon panel
(extended Yasko methylation panel)
BiONuMeRi tools 2016/2017
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| Paziente : Lilly Mendel | Data di creazione del report : 16 Apr 2024 |
| Defect in folate metabolism, impacting BH4 levels | ||||||
| Influence homocysteine levens and lowers folate levels. In homozygous mutation, sever psychomotor development and throbotic issues | ||||||
| Convert homocysteine to methionine. Together BHMT4 play a role in the gut | ||||||
| Convert homocysteine to methionine. Together BHMT4 play a role in the gut | ||||||
| Convert homocysteine to methionine. Together BHMT4 play a role in the gut | ||||||
| Convert homocysteine to methionine, BHMT8 is related to the impact that psychological stress has on attention levels | ||||||
| Together A360A and N212N convert homocysteine into cystathionine, when mutated lowers homocysteine level, raise ammonia, increase taurine, increase toxic sulfur products and reduce folic acid effect | ||||||
| Together C699T and N212N convert homocysteine into cystathionine, when mutated lowers homocysteine level, raise ammonia, increase taurine, increase toxic sulfur products and reduce folic acid effect | ||||||
| Together A360A and C699T convert homocysteine into cystathionine, when mutated lowers homocysteine level, raise ammonia, increase taurine, increase toxic sulfur products and reduce folic acid effect | ||||||
| Detoxify from sulfites | ||||||
| Degrades serotonin, melatonin, epinephrine and norepinephrine. It can lower the tryptophan levels. Together a COMT V158M mutation can give mood swings. Neutralizes tyramine (+/+ reduced activity -/- increased activity) | ||||||
| Degrades dopamine. It contributes to Parkinson's disease | ||||||
| Degrades dopamine. With A allele you have anxiety so high dopamine, low pain threshold, Stress vulnerability, greater cognitive performance. With G allele you are wrestler then you have low dopamine, high pain threshold, resistance to stress and lower cognitive performance. (+/+) Poorly tolerate to methyl donors. | ||||||
| Degrades dopamine. Susceptibility to schizophrenia | ||||||
| Degrades dopamine. | ||||||
| Work with MTRR to regenerate and use the B12 helping to convert homocysteine to methionine. The mutation can lower B12 levels. Converts MTHF in THF adding the methyl group to B12. | ||||||
| Work with MTR to regenerate and use the B12 helping to convert homocysteine to methionine. The mutation can lower B12 levels. Converts MTHF in THF adding the methyl group to B12. | ||||||
| Work with MTR to regenerate and use the B12 helping to convert homocysteine to methionine. The mutation can lower B12 levels. Converts MTHF in THF adding the methyl group to B12. | ||||||
| Work with MTR to regenerate and use the B12 helping to convert homocysteine to methionine. The mutation can lower B12 levels. Converts MTHF in THF adding the methyl group to B12. | ||||||
| Work with MTR to regenerate and use the B12 helping to convert homocysteine to methionine. The mutation can lower B12 levels. Converts MTHF in THF adding the methyl group to B12. | ||||||
| Work with MTR to regenerate and use the B12 helping to convert homocysteine to methionine. The mutation can lower B12 levels. Converts MTHF in THF adding the methyl group to B12. | ||||||
| (see MTR/MTRR) Generally people with MTRR11 mutated are good heavy metal excretor | ||||||
| The AHCY mutations limit the activity of homocysteine conversion to methionine. They can mitigate the effects of CBS mutations. | ||||||
| The AHCY mutations limit the activity of homocysteine conversion to methionine. They can mitigate the effects of CBS mutations. | ||||||
| The AHCY mutations limit the activity of homocysteine conversion to methionine. They can mitigate the effects of CBS mutations. | ||||||
| It helps to convert folic acid into 5MTHF. It transfers a methyl group from serine 5,10-methilene THF and glycine | ||||||
| Detoxify from ammonia | ||||||
| mitochondrial SOD (WARNING very difficult to identify, refer to http://www.snpedia.com/index.php/Rs4880 for alzheimer G risk allele) | ||||||
| extracellular SOD | ||||||
| Enzyme that promotes detoxification (Glutathione), a mutation causes a loss of function of the enzyme and less detoxification | ||||||
| see GSTP1 I105V | ||||||
| (+/+) Double deletion results in a loss of functionality of the enzyme and less detoxification | ||||||
| Affects dopamine levels | ||||||
| Affects blood sugar control and pancreatic function (possible adoption of a low-carbohydrate diet) | ||||||
| Affects dopamine levels, related to bone density. When mutated low vitamin D3 and D2 values. | ||||||
| Activate D vitamin | ||||||
| When mutated low values of Tocopherol (Vitamin E) | ||||||
| When mutated low vitamin B12 values. | ||||||
| When mutated low vitamin B6 values in the blood. | ||||||
| Together with two other GCH1, when mutated low values of tetrabiopterine (BH4) | ||||||
| Together with two other GCH1, when mutated low values of tetrabiopterine (BH4) | ||||||
| Together with two other GCH1, when mutated low values of tetrabiopterine (BH4) | ||||||
| When mutated, purine deficiency. T-cell immune deficiency | ||||||
| It contributes to the cholesterol synthesis and lipid balance of the cell membrane. Mediates the accumulation of oxalates. It contributes to energy production. | ||||||
| degrades ammonia into urea, may cause high blood ammonia, Increase Alzheimer's Risk. | ||||||
| Influences the GABA production, increases the risk of schizophrenia, (+/+) gaba significantly decreased, with comt v158m (+/-) (-/-) reduced cortical thickness | ||||||
| (+/+) associated with post-traumatic seizures and high glutamate levels, (+/-) average glutamate levels | ||||||
| Affects GABA levels. Complex attention! (+/-) Low levels, (+ / +) average levels, (- / -) high GABA levels | ||||||
| Affects GABA levels. (+/+) hight Glutamate, (+/-) intermediate levels | ||||||
| degrades ammonia into urea, if mutated high ammonia levels | ||||||
| degrades ammonia into urea, if mutated high ammonia levels |
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NB: Il presente pannello e' estratto elaborando il file di esoma 23andme.com fornito dall'utente, pertanto non si certifica la veridicita' dei dati pervenuti.
Il risultato del pannello non costituisce in alcun modo consiglio medico.
Ogni commento di ogni singolo snp non costituisce assoluta certezza ma deve essere vagliato da un medico e verificato da indagini mirate o da prove cliniche.
In questo pannello non viene presa in considerazione l'espressione genetica (epigenetica) ed i vari snp possono interferire tra loro enfatizzando o annullando determinati errori metabolici. Per maggiori dettagli e la bibliografia consultare la pagina http://www.bionumeri.org/esami/onecarbon.html |
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